As seen in the announcement trailer in the trailer for Diablo 4

 Lilith and Inarius gathered like-minded followers and retreated to Sanctuary for a break from the Eternal Conflict, and eventually, the demon and the rogue angel had Rathma, a first-generation nephalem, and the first child to be conceived between two such beings. Other nephalem followed, but the demons and rogue angels began to fear their new offspring's increasing strength and were frightened by this Diablo 4 Gold new breed of beings. Some wanted to wipe them out as well, and Lilith being concerned for her children and believing that they were the only way to end the war for good and peace, killed every follower of Inarius who wanted to destroy them.

Inarius was outraged by Lilith's treachery and brutality, and even though he couldn't bring himself to kill her and he was able to banish her to the Void. He also ensured that each subsequent generation of nephalem got weaker to avoid the issue with the rebel demons and angels were afraid of their offspring rebelling against them. But Lilith was honored in legend, referred to as the First Mother by some , and encouraging cults to revere her. Lilith returned to Sanctuary earlier and altered the potential of Worldstone to allow nephalem powers again. Even though Lilith is able to cause chaos and briefly return to Sanctuary in various guises, Inarius was successfully able to reinstate her banishment to the Void.

As seen in the announcement trailer in the trailer for Diablo 4. a member of the Triune managed to trick two adventurers as well as a scholar entering a sacred chamber in order that Lilith was finally freed many thousands of years after her initial banishment from Sanctuary. Lilith's return spurred a fresh crowd of worshipers and cultists throughout the world of mortals as her arrival was seen by some as a solution to ending this Eternal Conflict. Lilith awakens the darkest urges within the souls of all who come in contact with her, and the return of Lilith to Sanctuary is bound to cause a return of despair and darkness as well. Her final goal - to make sure that the nephalem will rise from the dead - is likely to be a central crux of Diablo 4's plot.

The developers have promised a much robust and grounded approach to Diablo 4's narrative compared to the predecessor Diablo 3. Although this Pandemonium Event in Diablo 2 is not strictly considered canon It could offer clues on how Lilith will pursue her plan of domination and it could also suggest that she will try the summoning of Diablo or other Prime Evils. If Lilith is looking to empower the nephalem in the future, this could also provide some interesting antagonists or strengthen the player's personal character as the game progresses well. Apart from Lilith's return, and the inexplicably vague details about the plans she has for Sanctuary there isn't much else that is revealed about Diablo 4's story as players were left to speculate prior to the game's release.

While Lilith was only briefly featured in the previous Diablo game, she's seen a complete revamp as part of her Diablo 4 incarnation. Lilith appears very different than her original Diablo 2 character model, and her new design demonstrates what level of detailing that the Cheap Diablo IV Gold developer is aiming for when it comes to the next installment and also an attempt to return to more traditional gothic style.